Saturday, April 24, 2010

What is the best oral treatment for syphilis in its last (third) stage, am 40 years.?

I have had lab test but all come out negative yet i have craks in between my toes. I also often get itchy skin rash among the toes that re cracked. I was managed on Erythromycin for 14 days but to no avail. Please i need an oral effective cure for syphilis if this is the disease am suffering from.|||Please get tests and get an second opinion if they will help . benzathine penicillin G or aqueous procaine penicillin G injections. Individuals who have severe allergic reactions to penicillin (e.g., anaphylaxis) may be effectively treated with oral tetracyclines.





Oral Azithromycin given as a single dose of 2g has been used successfully to treat syphilis in a pilot study of 328 patients in Tanzania (Riedner 2005), but resistance to azithromycin has been reported in the US and elsewhere, which makes it doubtful that this treatment will become widespread in the US.








Syphilis can be treated with penicillin or other antibiotics. Statistically, treatment with a course of pills is dramatically less effective than other treatments, because patients tend not to complete the course. The oldest, and still most effective, method is to inject benzathine penicillin into each buttock (procaine is added to make the pain bearable); the dose must be given half in each buttock because the amount given would be too painful if given in a single injection. An alternative treatment is to administer several tablets of azithromycin orally (which has a long duration of action) under observation. This latter course, however, may be falling on hard times, as strains of syphilis resistant to azithromycin have developed and may account for 10% of cases in some areas in 2004. Other treatments are less effective as the patient is required to take pills several times a day.





If not treated, syphilis can cause serious effects such as damage to the nervous system, heart, or brain. Untreated sypStages of syphilis


Different manifestations occur at each stage of the disease.





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Primary syphilis





Chancres on penis due to primary syphilitic infectionPrimary syphilis is manifested after an incubation period of 10-90 days (the average is 21 days) with a primary sore. During the initial incubation period, individuals are asymptomatic. The sore, called a chancre, is a firm, painless skin ulceration localized at the point of initial exposure to the bacterium, often on the penis, vagina or rectum. Local lymph node swelling can occur. The primary lesion may persist for 4 to 6 weeks and then heal spontaneously.





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Secondary syphilis





Secondary syphilis manifested on labiaSecondary syphilis is characterized by a skin rash that appears 1-6 months (commonly 6 to 8 weeks) after the primary infection. This is a symmetrical reddish-pink non-itchy rash on the trunk and extremities, which unlike most other kinds of rash involves the palms of the hands and the soles of the feet; in moist areas of the body the rash becomes flat broad whitish lesions called condylomata lata. Mucous patches may also appear on the genitals or in the mouth. A patient with syphilis is most contagious when he or she has secondary syphilis.





Other symptoms common at this stage include fever, sore throat, malaise, weight loss, headache, meningismus, and enlarged lymph nodes. Rare manifestations include an acute meningitis that occurs in about 2% of patients, hepatitis, renal disease, hypertrophic gastritis, patchy proctitis, ulcerative colitis, rectosigmoid mass, arthritis, periostitis, optic neuritis, iritis, and uveitis.





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Tertiary syphilis


Tertiary syphilis occurs from as early as one year after the initial infection but can take up to ten years to manifest - though cases have been reported where this stage has occurred fifty years after initial infection. This stage is characterised by gummas, soft, tumor-like growths, readily seen in the skin and mucous membranes, but which can occur almost anywhere in the body, often in the skeleton. Other characteristics of untreated syphilis include Charcot's joints (joint deformity), and Clutton's joints (bilateral knee effusions). The more severe manifestations include neurosyphilis and cardiovascular syphilis.





Neurological complications at this stage include generalized paresis of the insane which results in personality changes, changes in emotional affect, hyperactive reflexes, and Argyll-Robertson pupils, a diagnostic sign in which the small and irregular pupils constrict in response to focusing the eyes, but not to light; Tabes dorsalis, also known as locomotor ataxia, a disorder of the spinal cord, often results in a characteristic shuffling gait.





Cardiovascular complications include aortic aortitis, aortic aneurysm, aneurysm of sinus of Valsalva, and aortic regurgitation, and are a frequent cause of death. Syphilitic aortitis can cause de Musset's sign (a bobbing of the head that de Musset first noted in Parisian prostitutes).





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Latent syphilis


Latent syphilis is defined as having serologic proof of infection without signs or symptoms of disease. Latent syphilis is further described as either early or late. Early latent syphilis is defined as having syphilis for one year or less from time of initial infection without signs or symptoms of disease. Late latent syphilis, then, is infection for greater than one year but having no clinical evidence of disease. The distinction is important for two reasons, therapy and risk for transmission.





In practice, the time of initial infection is often not known and in this case should then be presumed to be late for the purpose of therapy. Early latent syphilis may be treated with a single IM injection of a long-acting penicillin. Late latent syphilis, however, requires three such injections, each a week apart. For infectiousness, however, late latent syphilis is not considered contagious while early latent is. Thus, if the duration of infection is not known, one should presume the patient is early and contagious.





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Congenital syphilis


Congenital syphilis is syphilis present in utero and at birth, and occurs when a child is born to a mother with secondary or tertiary syphilis. Fetus in the utero is most liable to be infected with syphilis after the fifth month. According to the CDC, 40% of births to syphilitic mothers are stillborn, 40-70% of the survivors will be infected, and 12% of these will subsequently die prematurely. Manifestations of congenital syphilis include abnormal x-rays; Hutchinson's teeth (centrally notched, widely-spaced peg-shaped upper central incisors); mulberry molars (sixth year molars with multiple poorly developed cusps); frontal bossing; saddle nose; poorly developed maxillae; enlarged liver; enlarged spleen; petechiae; other skin rash; anemia; lymph node enlargement; jaundice; pseudoparalysis; and snuffles, the name given to rhinitis in this situation. Rhagades, linear scars at the angles of the mouth and nose result from bacterial infection of skin lesions. Death from congenital syphilis is usually through pulmonary hemorrhage.Affected children are highly infectious until about 2 years of age.


hilis can be fatal|||You need to see a different doc, syphilis can kill you!|||You had STD between your toes? I would think it would make itself know in other places of your body. Are you sure you do not have a severe case of athletes foot? Do you know something you are not letting on here?|||If lab tests came back negative, maybe you do not have syphillis, but instead have something like athlete's foot.





Read here for details about syphilis: http://en.wikipedia.org/wiki/Syphilis








If you have 3rd stage syphilis, you would be close to death.


You need to go see a different doctor and find out for sure what you have.





If your only symptom is cracks on your toes, perhaps you have a very simple fungus called Athlete's Foot.





Read here for more info on this condition: http://www.podiatrychannel.com/athletesf...|||I believe your doctor. Are you sure you have this? the tests can be negative, yes, but the condition is curable. If you have it the physician would give you medication and kill the spirochetes...if he can not, then how can anyone else? I know a woman who had it and she did not know it for a few years...when she had surgery they discovered it. she was then given medication and cured. keep putting triple antibiotic cream between your toes. I think I would ask the physician to hospitalize me and give me a strong dose of PCN IV. Penicillin intravenously.|||I dont think you have syphillis. I think you have althletes foot. Which is probably why the Erythromycin didn't work. Erythromycin treats infections. You have more of a Fungal problem. Try using tinactin or micatin. that should clear it up in a few days. Third stage Syphillis is deadly you would definatley know if you had it.|||why do you think you have syphilis ...if the tests were neg.sounds like you have a foot fungus to me... Athlete foot include itching and burning feet. The skin frequently peels and, in particularly severe cases, there may be some cracking, pain and bleeding as well.





When the skin is injured by the fungus, bacteria can also invade the skin. These bacteria can cause a bad smell. Bacterial infection of the skin and resulting inflammation is known as cellulitis. This is especially likely to occur in the elderly, individuals with diabetes, chronic leg swelling, or who have had veins removed (such as for heart bypass surgery), and patients with impaired immune systems.

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